組織学的研究支援室実績

論文

2025

1. Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions
   Takumi Mikawa , Masahiro Kameda , Sumiko Ikari , Eri Shibata , Shuyu Liu , Sawa Miyagawa , Koh Ono , Tomiko Ito , Akihiko Yoshizawa , Masataka Sugimoto, Shuichi Shibuya , Takahiko Shimizu , Julio Almunia , Noboru Ogiso , Gwladys Revêchon , Alberta Palazzo, David Bernard , Hiroaki Kanda , Tomoyoshi Soga , Keiyo Takubo , Shin Morioka , Junko Sasaki , Takehiko Sasaki , Akihiro Itamoto , Takayuki Fujii , Hiroshi Seno , Nobuya Inagaki , Hiroshi Kondoh
   Signal Transduct Target Ther. 2025 Dec 15;10(1):402.
   DOI: 10.1038/s41392-025-02502-6
2. Stem-like and effector peripheral helper T cells comprise distinct subsets in rheumatoid arthritis
   Yuki Masuo , Akinori Murakami , Rinko Akamine , Osamu Iri , Shunsuke Uno , Koichi Murata , Kohei Nishitani , Hiromu Ito , Ryu Watanabe , Takayuki Fujii , Takeshi Iwasaki , Shinichiro Nakamura , Shinichi Kuriyama , Yugo Morita , Yasuhiro Murakawa , Chikashi Terao , Yukinori Okada , Motomu Hashimoto , Shuichi Matsuda , Hideki Ueno , Hiroyuki Yoshitomi
   Sci Immunol. 2025 Aug 15;10(110):eadt3955.
   DOI: 10.1126/sciimmunol.adt3955
3. Human CD4⁺ T cells regulate peripheral immune responses in rheumatoid arthritis via insulin-like growth factor-like family member 2
   Akinori Murakami , Rinko Akamine , Shiro Tanaka , Koichi Murata , Kohei Nishitani , Hiromu Ito , Ryu Watanabe , Takayuki Fujii , Takeshi Iwasaki , Yuki Masuo , Osamu Iri , Shinichiro Nakamura , Shinichi Kuriyama , Yugo Morita , Yasuhiro Murakawa , Chikashi Terao , Yukinori Okada , Motomu Hashimoto , Shuichi Matsuda , Hideki Ueno , Hiroyuki Yoshitomi
   Sci Immunol. 2025 Aug;10(110):eadr3838.
   DOI: 10.1126/sciimmunol.adr3838
4. Rat Tracheal Cartilage Regeneration Using Mesenchymal Stem Cells Derived From Human iPS Cells
   Keisuke Mizuno , Hiroe Ohnishi , Yo Kishimoto , Tsuyoshi Kojima , Shintaro Fujimura , Yoshitaka Kawai , Masayuki Kitano , Makoto Ikeya , Koichi Omori
   Tissue Eng Part A. 2025 May;31(9-10):398-408.
   DOI: 10.1089/ten.TEA.2024.0151
5. Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy
   Reo Hata , Shunsuke Funakoshi , Takeru Makiyama , Takao Kato , Megumi Narita , Yasuko Matsumura , Ryoko Hirohata , Yuki Naka , Kazumi Ida , Hiroaki Ito , Akihiko Yoshizawa , Yasuhito Nannya , Hironori Haga , Seishi Ogawa , Koh Ono , Takeshi Kimura , Yoshinori Yoshida
   JACC Basic Transl Sci. 2025 Sep 10;10(10):101363.
   DOI: 10.1016/j.jacbts.2025.101363
6. Cdkn1c orchestrates a molecular network that regulates euploidy of male mouse germline stem cells
   Mito Kanatsu-Shinohara , Takuya Yamamoto , Tianjiao Liu , Keiichi I Nakayama , Takashi Shinohara
   Development. 2025 Feb 15;152(4):dev204286.d
   DOI: 10.1242/dev.204286
7. Cholangiocyte organoids for disease, cancer, and regenerative medicine
   Munemasa Nagao , Akihisa Fukuda , Hirotaka Kashima , Sho Matsuyama , Kei Iimori , Shinnosuke Nakayama , Kenta Mizukoshi , Munenori Kawai , Go Yamakawa , Mayuki Omatsu , Mio Namikawa , Tomonori Masuda , Yukiko Hiramatsu , Yu Muta , Takahisa Maruno , Yuki Nakanishi , Tatsuaki Tsuruyama , Hiroshi Seno
   Eur J Cell Biol. 2025 Mar;104(1):151472.
   DOI: 10.1016/j.ejcb.2024.151472
8. Chronic expanding hematoma following Gamma Knife irradiation for primary central nervous system lymphoma: illustrative case
   Etsuko Yamamoto Hattori , Yukinori Terada , Yasuhide Takeuchi , Yasuhide Makino , Shigeki Takada , Noritaka Sano , Masahiro Tanji , Yohei Mineharu , Yoshiki Arakawa
   J Neurosurg Case Lessons. 2025 Apr 21;9(16):
   DOI: 10.3171/CASE258
9. The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells
   May Nakajima-Koyama , Mio Kabata , Joonseong Lee , Yuko Sogabe , Satoko Sakurai , Akira Hirota , Mizuki Kimura , Tomonori Nakamura , Yusuke Imoto , Kohei Kometani , Yoko Hamazaki , Yasuaki Hiraoka , Mitinori Saitou , Eisuke Nishida , Takuya Yamamoto
   Cell Rep. 2025 Mar 25;44(3):115286.
   DOI: 10.1016/j.celrep.2025.115286

2024

1. Ferroptosis-related gene glutathione peroxidase 4 promotes reprogramming of glucose metabolism via Akt-mTOR axis in intrahepatic cholangiocarcinoma
   Yutaro Hori , Tomoaki Yoh , Hiroto Nishino , Keisuke Okura , Makoto Kurimoto , Yuichi Takamatsu , Motohiko Satoh , Takahiro Nishio , Yukinori Koyama , Takamichi Ishii , Keiko Iwaisako , Satoru Seo , Etsuro Hatano
   Carcinogenesis. 2024 Mar 11;45(3):119-130.
   DOI: 10.1093/carcin/bgad094
2. EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development
   Hiroki Kagoshima , Hiroe Ohnishi , Ryosuke Yamamoto , Akiyoshi Yasumoto , Yosuke Tona , Takayuki Nakagawa , Koichi Omori , Norio Yamamoto
   J Neurosci. 2024 Feb 14;44(7):e1060232023.
   DOI: 10.1523 /JNEUROSCI.1060-23.2023
3. A Deep Learning-Based Assessment Pipeline for Intraepithelial and Stromal Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Carcinoma
   Kohei Hamada , Ryusuke Murakami , Akihiko Ueda , Yoko Kashima , Chiho Miyagawa , Mana Taki , Koji Yamanoi , Ken Yamaguchi , Junzo Hamanishi , Sachiko Minamiguchi , Noriomi Matsumura , Masaki Mandai
   Am J Pathol. 2024 Jul;194(7):1272-1284.
   DOI: 10.1016/j.ajpath.2024.02.016
4. Hyposecretion of cervical MUC5B is related to preterm birth in pregnant women after cervical excisional surgery
   Yusuke Ueda , Haruta Mogami , Yoshitsugu Chigusa , Yosuke Kawamura , Asako Inohaya , Masahito Takakura , Eriko Yasuda , Yu Matsuzaka , Miho Shimada , Shinji Ito , Satoshi Morita , Masaki Mandai , Eiji Kondoh
   Am J Reprod Immunol. 2024 Mar;91(3)
   DOI: 10.1111/aji.13832
5. Non-cell-autonomous suppression of tumor growth by RECK in immunocompetent mice
   Tomoko Matsuzaki , Joe Inoue , Nagahiro Minato , Makoto Noda
   J Cell Physiol. 2024 Sep;239(9):e31396.
   DOI: 10.1002/jcp.31396
6. Combination Therapy with EGFR Tyrosine Kinase Inhibitors and TEAD Inhibitor Increases Tumor Suppression Effects in EGFR Mutation-positive Lung Cancer
   Tatsuya Ogimoto , Hiroaki Ozasa , Takahiro Tsuji , Tomoko Funazo , Masatoshi Yamazoe , Kentaro Hashimoto , Hiroshi Yoshida , Kazutaka Hosoya , Hitomi Ajimizu , Takashi Nomizo , Hironori Yoshida , Masatsugu Hamaji , Toshi Menju , Akihiko Yoshizawa , Hiroshi Date , Toyohiro Hirai
   Mol Cancer Ther. 2024 Apr 2;23(4):564-576.
   DOI: 10.1158/1535-7163.MCT-23-0371
7. EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development
   Hiroki Kagoshima , Hiroe Ohnishi , Ryosuke Yamamoto , Akiyoshi Yasumoto , Yosuke Tona , Takayuki Nakagawa , Koichi Omori , Norio Yamamoto
   J Neurosci. 2024 Feb 14;44(7):e1060232023.
   DOI: 10.1523/JNEUROSCI.1060-23.2023

2023

1. Evolutionary histories of breast cancer and related clones
   Tomomi Nishimura, Nobuyuki Kakiuchi, Kenichi Yoshida, Takaki Sakurai, Tatsuki R. Kataoka, Eiji Kondoh, Yoshitsugu Chigusa, Masahiko Kawai, Morio Sawada, Takuya Inoue, Yasuhide Takeuchi, Hirona Maeda, Satoko Baba, Yusuke Shiozawa, Ryunosuke Saiki, Masahiro M. Nakagawa, Yasuhito Nannya, Yotaro Ochi, Tomonori Hirano, Tomoe Nakagawa, Yukiko Inagaki-Kawata, Kosuke Aoki, Masahiro Hirata, Kosaku Nanki, Mami Matano, Megumu Saito, Eiji Suzuki, Masahiro Takada, Masahiro Kawashima, Kosuke Kawaguchi, Kenichi Chiba, Yuichi Shiraishi, Junko Takita, Satoru Miyano, Masaki Mandai, Toshiro Sato, Kengo Takeuchi, Hironori Haga, Masakazu Toi & Seishi Ogawa
   Nature volume 620, pages607–614 (2023)
   DOI: 10.1038/s41586-023-06333-9
2. Novel and efficient method for culturing patient-derived gastric cancer stem cells
   Tomonori Morimoto , Yukitoshi Takemura , Takemitsu Miura , Takehito Yamamoto , Fumihiko Kakizaki , Hideo An , Hisatsugu Maekawa , Tadayoshi Yamaura , Kenji Kawada , Yoshiharu Sakai , Yoshiaki Yuba , Hiroaki Terajima , Kazutaka Obama , Makoto Mark Taketo , Hiroyuki Miyoshi
   Cancer Sci. 2023 Aug;114(8):3259-3269.
   DOI: 10.1111/cas.15840.
3. Carbon nanotube recognition by human Siglec-14 provokes inflammation
   Shin-Ichiro Yamaguchi, Qilin Xie, Fumiya Ito, Kazuki Terao, Yoshinobu Kato, Miki Kuroiwa, Satoshi Omori, Hideo Taniura, Kengo Kinoshita, Takuya Takahashi, Shinya Toyokuni, Kota Kasahara & Masafumi Nakayama
   Nature Nanotechnology volume 18, pages628–636 (2023).
   DOI: 10.1038/s41565-023-01363-w
4. M2-like tumor-associated macrophages promote epithelial-mesenchymal transition through the transforming growth factor β/Smad/zinc finger e-box binding homeobox pathway with increased metastatic potential and tumor cell proliferation in lung squamous cell carcinoma
   Ryota Sumitomo , Toshi Menju , Yumeta Shimazu , Toshiya Toyazaki , Naohisa Chiba , Hideaki Miyamoto , Yutaka Hirayama , Shigeto Nishikawa , Satona Tanaka , Yojiro Yutaka , Yoshito Yamada , Daisuke Nakajima , Akihiro Ohsumi , Masatsugu Hamaji , Atsuyasu Sato , Akihiko Yoshizawa , Cheng-Long Huang , Hironori Haga , Hiroshi Date
   Cancer Science114(12) . 2023 Dec;114(12):4521-4534.
   DOI: 10.1111/cas.15987
5. Laryngeal Cartilage Regeneration of Nude Rats by Transplantation of Mesenchymal Stem Cells Derived from Human-Induced Pluripotent Stem Cells
   Keisuke Mizuno , Hiroe Ohnishi , Masayoshi Yoshimatsu , Chengzhu Zhao , Yasuyuki Hayashi , Fumihiko Kuwata , Shinji Kaba , Hideaki Okuyama , Yoshitaka Kawai , Nao Hiwatashi , Yo Kishimoto , Tatsunori Sakamoto , Makoto Ikeya , Koichi Omori
   Cell Transplant. 2023
   DOI: 10.1177/09636897231178460
6. An exploratory study for tuft cells in the breast and their relevance in triple-negative breast cancer: the possible relationship of SOX9
   Yosuke Yamada , Ronald Simon , Kosuke Iwane , Yuki Nakanishi , Yasuhide Takeuchi , Akihiko Yoshizawa , Masahiro Takada , Masakazu Toi , Hironori Haga , Alexander Marx , Guido Sauter
   BMC Cancer. 2023 May 13;23(1):438.
   DOI: 10.1186/s12885-023-10949-5
7. Systemic amyloidosis with amyloid goiter: An autopsy report
   Chihiro Kawai , Masashi Miyao , Hirokazu Kotani , Hirozo Minami , Hitoshi Abiru , Hideki Hamayasu , Akira Yamamoto , Keiji Tamaki
   Leg Med (Tokyo). 2023 Feb:60:102167
   DOI: 10.1016/j.legalmed.2022.102167

2022

1. Improved anti-solid tumor response by humanized anti-podoplanin chimeric antigen receptor transduced human cytotoxic T cells in an animal model
   Akihiro Ishikawa , Masazumi Waseda , Tomoko Ishii , Mika K Kaneko , Yukinari Kato , Shin Kaneko
   Genes Cells. 2022 Sep;27(9):549-558.
   DOI: 10.1111/gtc.12972.
2. Cervical MUC5B and MUC5AC are Barriers to Ascending Pathogens During Pregnancy
   Yusuke Ueda , Haruta Mogami , Yosuke Kawamura , Masahito Takakura , Asako Inohaya , Eriko Yasuda , Yu Matsuzaka , Yoshitsugu Chigusa , Shinji Ito , Masaki Mandai , Eiji Kondoh
   J Clin Endocrinol Metab. 2022 Nov 23;107(11):3010-3021.
   DOI: 10.1210/clinem/dgac545
3. Fetal macrophages assist in the repair of ruptured amnion through the induction of epithelial-mesenchymal transition
   Yosuke Kawamura , Haruta Mogami , Eriko Yasuda , Masahito Takakura , Yu Matsuzaka , Yusuke Ueda , Asako Inohaya , Kaoru Kawasaki , Yoshitsugu Chigusa , Masaki Mandai , Eiji Kondoh
   Sci Signal. 2022 Sep 13;15(751):
   DOI: 10.1126/scisignal.abi5453
4. A proof-of-concept study to construct Bayesian network decision models for supporting the categorization of sudden unexpected infant death
   Hideki Hamayasu, Masashi Miyao, Chihiro Kawai, Toshio Osamura, Akira Yamamoto, Hirozo Minami, Hitoshi Abiru, Keiji Tamaki & Hirokazu Kotani
   Scientific Reportsvolume 12, Article number: 9773 (2022)
   DOI: 10.1038/s41598-022-14044-w
5. Fatal Dieulafoy lesion with IgG4-related disease: An autopsy case report
   Masashi Miyao , Chihiro Kawai , Hirokazu Kotani , Hirozo Minami , Hitoshi Abiru , Hideki Hamayasu , Akira Yamamoto , Keiji Tamaki
   Leg Med (Tokyo). 2022 Jul:57:102059.
   DOI: 10.1016/j.legalmed.2022.102059

2021

1. Differentiation of Hypertrophic Chondrocytes from Human iPSCs for the In Vitro Modeling of Chondrodysplasias
   Yann Pretemer , Shunsuke Kawai , Sanae Nagata , Megumi Nishio , Makoto Watanabe , Sakura Tamaki , Cantas Alev , Yoshihiro Yamanaka , Jing-Yi Xue , Zheng Wang , Kenichi Fukiage , Masako Tsukanaka , Tohru Futami , Shiro Ikegawa , Junya Toguchida
   Stem Cell Reports. 2021 Mar 9;16(3):610-625.
   DOI: 10.1016/j.stemcr.2021.01.014.
2. Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissues
   Hiroaki Osada , Masahide Kawatou , Daiki Fujita , Yasuhiko Tabata , Kenji Minatoya , Jun K Yamashita , Hidetoshi Masumoto
   JTCVS Open. 2021 Oct 1:8:359-374.
   DOI: 10.1016/j.xjon.2021.09.038.
3. Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations
   Mitsuhiro Nikaido , Nobuyuki Kakiuchi , Shin’ichi Miyamoto , Tomonori Hirano , Yasuhide Takeuchi , Taro Funakoshi , Akira Yokoyama , Tatsuki Ogasawara , Yoshihiro Yamamoto , Atsushi Yamada , Takeshi Setoyama , Takahiro Shimizu , Yukari Kato , Suguru Uose , Takaki Sakurai , Sachiko Minamiguchi , Kazutaka Obama , Yoshiharu Sakai , Manabu Muto , Tsutomu Chiba , Seishi Ogawa , Hiroshi Seno
   Gastric Cancer. 2021 Sep;24(5):1102-1114.
   DOI: 10.1007/s10120-021-01191-8.
4. Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells
   Mai Sato, Asako Inohaya, Eriko Yasuda, Haruta Mogami, Yoshitsugu Chigusa, Kaoru Kawasaki, Yosuke Kawamura, Yusuke Ueda, Hiroshi Takai, Masaki Mandai & Eiji Kondoh
   Scientific Reports volume 11, Article number: 14167 (2021) Cite this article
   DOI:10.1038/s41598-021-93766-9
5. Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo.
   Satoshi Ikeo, Yuki Yamamoto , Kazuhiro Ikeda , Naoyuki Sone , Yohei Korogi , Lucia Tomiyama , Hisako Matsumoto , Toyohiro Hirai , Masatoshi Hagiwara , Shimpei Gotoh.
   Biomaterials, 2021 Sep;276:121031
   doi: 10.1016/j.biomaterials.2021.121031
6. Cutaneous T-cell-attracting chemokine as a novel biomarker for predicting prognosis of idiopathic pulmonary fibrosis: a prospective observational study.
   Takafumi Niwamoto, Tomohiro Handa , Yuko Murase , Yoshinari Nakatsuka , Kiminobu Tanizawa , Yoshio Taguchi , Hiromi Tomioka , Keisuke Tomii , Hideo Kita , Michihiro Uyama , Michiko Tsuchiya, Masahito Emura, Tetsuji Kawamura , Naoki Arai , Machiko Arita , Kazuko Uno , Akihiko Yoshizawa, Ryuji Uozumi, Izumi Yamaguchi , Fumihiko Matsuda, Kazuo Chin , Toyohiro Hirai.
   Respir Res, 2021 Jun17;22(1):181
   doi: 10.1186/s12931-021-01779-9
7. Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells.
   Ryoji Kawakami , Yohko Kitagawa , Kelvin Y Chen , Masaya Arai , Daiya Ohara , Yamami Nakamura , Keiko Yasuda , Motonao Osaki , Norihisa Mikami , Caleb A Lareau , Hitomi Watanabe , Gen Kondoh , Keiji Hirota , Naganari Ohkura , Shimon Sakaguchi.
   Immunity, 2021 May 11;54(5):947-961.e8
   doi: 10.1016/j.immuni.2021.04.005
8. Tomoko Kato Norio Harada , Eri Ikeguchi-Ogura , Akiko Sankoda , Tomonobu Hatoko , Xuejing Lu , Takuma Yasuda , Shunsuke Yamane , Nobuya Inagaki 
   J Mol Endocrinol 2021 Jan;66(1):11-22

2020

1. YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation
   Takahiro Tsuji, Hiroaki Ozasa, Wataru Aoki, Shunsuke Aburaya, Tomoko Yamamoto Funazo, Koh Furugaki, Yasushi Yoshimura, Masatoshi Yamazoe, Hitomi Ajimizu, Yuto Yasuda, Takashi Nomizo, Hironori Yoshida, Yuichi Sakamori, Hiroaki Wake, Mitsuyoshi Ueda, Young Hak Kim & Toyohiro Hirai
   Nature Communications volume 11, Article number: 74 (2020)
   DOI: 10.1038/s41467-019-13771-5
2. MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-X_L expression
   Yuto Yasuda, Hiroaki Ozasa, Young Hak Kim, Masatoshi Yamazoe, Hitomi Ajimizu, Tomoko Yamamoto Funazo, Takashi Nomizo, Takahiro Tsuji, Hironori Yoshida, Yuichi Sakamori, Naoki Nakajima, Toshi Menju, Akihiko Yoshizawa, Hiroshi Date & Toyohiro Hirai
   Cell Death & Disease volume 11, Article number: 177 (2020)
   DOI: 10.1038/s41419-020-2379-2
3. Fatal Mumps Myocarditis Associated with Left Ventricular Non-Compaction
   Leila Jemail , Masashi Miyao , Hideki Hamayasu , Hirozo Minami , Hitoshi Abiru , Shiro Baba , Toshio Osamura , Keiji Tamaki , Hirokazu Kotani
   Am J Case Rep. 2020 Mar 30:21:e921177.
   DOI: 10.12659/AJCR.921177
4. Trp53 Mutation in Keratin 5 (Krt5)-Expressing Basal Cells Facilitates the Development of Basal Squamous-Like Invasive Bladder Cancer in the Chemical Carcinogenesis of Mouse Bladder.
   Masuda N, Murakami K, Kita Y, Hamada A, Kamada M, Teramoto Y, Sakatani T, Matsumoto K, Sano T, Saito R, Okuno Y, Ogawa O, Kobayashi T.
   Am J Pathol, 2020 Aug;190(8):1752-1762
   doi: 10.1016/j.ajpath.2020.04.005
5. “Epub 2020 Apr 28. SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice”.
   Satoshi Ogawa, Ueda M, Kono J, Sano T, Nishikawa N, Kunisue S, Tsujihana K, Liou LS, Kanematsu A, Shimba S, Doi M, Okamura H, Ogawa O, Negoro H.
   Gastroenterology, 2020 Aug;159(2):682-696.e13
   doi: 10.1038/s41598-018-20379-0
6. The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation
   Seiichiro Tada Takayuki Anazawa , Takero Shindo , Kei Yamane , Kenta Inoguchi , Nanae Fujimoto , Kazuyuki Nagai , Toshihiko Masui , Hideaki Okajima , Kyoichi Takaori , Shoichiro Sumi , Shinji Uemoto
   Transplant Direct 2020 Aug 12;6(9):e591 
   doi: 10.1097/TXD.0000000000001045
7. Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes
   Ayana Kon , Toyonori Sakata , Masahiro M Nakagawa , Naotaka Nakazawa , Masanori Kakuta , Keisuke Kataoka , Haruhiko Koseki , Manabu Nakayama , Daisuke Morishita , Tatsuaki Tsuruyama , Ryunosuke Saiki , Akinori Yoda , Rurika Okuda , Tetsuichi Yoshizato , Kenichi Yoshida , Yusuke Shiozawa , Yasuhito Nannya , Shinichi Kotani , Yasunori Kogure , Nobuyuki Kakiuchi , Tomomi Nishimura , Hideki Makishima , Luca Malcovati , Akihiko Yokoyama , Kengo Takeuchi , Eiji Sugihara , Taka-Aki Sato , Masashi Sanada , Akifumi Takaori-Kondo , Mario Cazzola , Mineko Kengaku , Satoru Miyano , Katsuhiko Shirahige , Hiroshi I Suzuki , Seishi Ogawa 
   Cancer Discov 2020 Jun;10(6):836-853 
   doi: 10.1158/2159-8290.CD-19-0982
8. Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR1
   Hirotsugu Maekawa , Shunsuke Kawai , Megumi Nishio, Sanae Nagata , Yonghui Jin , Hiroyuki Yoshitomi , Shuichi Matsuda , Junya Toguchida
   Orphanet J Rare Dis 2020 May 24;15(1):122 
   doi: 10.1186/s13023-020-01406-8
9. Homeobox A4 suppresses vascular remodeling by repressing YAP/TEAD transcriptional activity
   Masahiro Kimura , Takahiro Horie , Osamu Baba , Yuya Ide , Shuhei Tsuji , Randolph Ruiz Rodriguez , Toshimitsu Watanabe , Tomohiro Yamasaki , Chiharu Otani , Sijia Xu , Yui Miyasaka 1, Yasuhiro Nakashima 1, Takeshi Kimura 1, Koh Ono 1
   EMBO Rep 2020 Apr 3;21(4)e48389
   doi: 10.15252/embr.201948389
10. Anti-VEGF therapy resistance in ovarian cancer is caused by GM-CSF-induced myeloid-derived suppressor cell recruitment
    Kaoru Abiko, Noriomi Matsumura, Tsukasa Baba, Junzo Hamanishi , Ken Yamaguchi , Ryusuke Murakami, Mana Taki, Masayo Ukita, Yuko Hosoe, Masafumi Koshiyama, Ikuo Konishi, Masaki Mandai Br
    J Cancer 2020 Mar;122(6):778-788.
    doi: 10.1038/s41416-019-0725-x

2019

1. Kita Y, Hamada A, Saito R, Teramoto Y, Tanaka R, Takano K, Nakayama K, Murakami K, Matsumoto K, Akamatsu S, Yamasaki T, Inoue T, Tabata Y, Okuno Y, Ogawa O, Kobayashi T.
   Systematic chemical screening identifies disulfiram as a repurposed drug that enhances sensitivity to cisplatin in bladder cancer: a summary of preclinical studies
   Br J Cancer 2019 Dec;121(12):1027-1038
   doi: 10.1038/s41416-019-0609-0
2.  Yoshika Iwata , Kenichiro Tatsumi , Yoshimitsu Miyai , Tomonori Matsuyama , Tomoharu Tanaka 
   Maternal exposure to volatile anesthetics induces IL-6 in fetal brains and affects neuronal development
   Eur J Pharmacol 2019 Nov 15;863:172682
   doi: 10.1016/j.ejphar.2019.172682
3. Saori Goto , Koya Hida , Nobuaki Hoshino , Shigeo Hisamori , Kenji Kawada , Takaki Sakurai , Yoshiharu Sakai Asian
   Laparoscopic rectal tumor surgery after administration of a new sclerosing therapy (aluminum potassium sulfate and tannic acid injection) for internal hemorrhoids: A report of three cases
   J Endosc Surg 2019 Oct;12(4):473-477
   doi:10.1111/ases.12664
4. Tsukasa Baba, Kaoru Abiko, Junzo Hamanishi, Ken Yamaguchi, Ryusuke Murakami, Mana Taki, Yuko Hosoe, Susan K Murphy, Ikuo Konishi, Masaki Mandai, Noriomi Matsumura 
   Acquisition of a side population fraction augments malignant phenotype in ovarian cancer
   Sci Rep 2019 Oct 2;9(1):14215
   doi: 10.1038/s41598-019-50794-w
5. Tsukasa Baba, Junzo Hamanishi, Noriomi Matsumura, Budiman Kharma, Yuka Mise, Kaoru Abiko , Ken Yamaguchi , Naoki Horikawa, David G Hunstman, Kumuluzi Mulati, Sachiko Kitamura, Mana Taki, Ryusuke Murakami, Yuko Hosoe, Masaki MandaiInt
   Phosphorylation of STAT1 serine 727 enhances platinum resistance in uterine serous carcinoma
   J Cancer 2019 Sep 15;145(6):1635-1647
   doi: 10.1002/ijc.32501
6. Isao Hirabayashi, A Richard Palmer
   Remarkably loud snaps during mouth-fighting by a sponge-dwelling worm
   Curr Biol 2019 Jul8;29(13):R617-R618
   doi:10.1016/j.cub.2019.05.047
7. Tomohiro Handa , Ran Nakashima , Kiminobu Tanizawa , Takeshi Kubo , Yuko Murase , Akihiko Sokai , Kohei Ikezoe , Yuji Hosono , Kizuku Watanabe , Shinsaku Tokuda , Kazuko Uno , Akihiko Yoshizawa , Tatsuaki Tsuruyama , Ryuji Uozumi , Sonoko Nagai , Kazuhiro Hatta , Yoshio Taguchi , Michiaki Mishima , Kazuo Chin , Tsuneyo Mimori , Toyohiro Hirai 
   Serum matrix metalloproteinase levels in polymyositis/dermatomyositis patients with interstitial lung disease
   Rheumatology (Oxford) 2019 Mar8;kez065
   doi: 10.1093/rheumatology/kez065
8. Junzo Hamanishi, Noriomi Matsumura, Kenji Chamoto, Nathan Mise, Kaoru Abiko, Tsukasa Baba, Ken Yamaguchi , Naoki Horikawa, Ryusuke Murakami, Mana Taki, Kharma Budiman, Xiang Zeng, Yuko Hosoe, Miyuki Azuma, Ikuo Konishi, Masaki Mandai 
   VISTA expressed in tumour cells regulates T cell function
   Br J Cancer 2019 Jan;120(1):115-127 
   doi: 10.1038/s41416-018-0313-5
9. Uegaki M, Kita Y, Shirakawa R, Teramoto Y, Kamiyama Y, Saito R, Yoshikawa T, Sakamoto H, Goto T, Akamatsu S, Yamasaki T, Inoue T, Suzuki A, Horiuchi H, Ogawa O, Kobayashi T.
   Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis.
   Carcinogenesis 2019 May 6. pii: bgz082
   doi: 10.1093/carcin/bgz082
10. Miyazaki Y, Teramoto Y, Shibuya S, Goto T, Okasho K, Mizuno K, Uegaki M, Yoshikawa T, Akamatsu S, Kobayashi T, Ogawa O, Inoue T
    Consecutive Prostate Cancer Specimens Revealed Increased Aldo⁻Keto Reductase Family 1 Member C3 Expression with Progression to Castration-Resistant Prostate Cancer.
    J Clin Med 2019 May 1;8(5). pii: E601
    doi: 10.3390/jcm8050601

2018

1. Koichiro Hata , Yusuke Okamura , Yermek Nigmet , Hirofumi Hirao , Toyonari Kubota 1, Osamu Inamoto , Jiro Kusakabe , Toru Goto , Tetsuya Tajima , Junichi Yoshikawa , Hirokazu Tanaka , Tatsuaki Tsuruyama , Rene H Tolba , Shinji Uemoto 
   Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury
   Liver Transpl 2018 Nov;24(11):1589-1602 
   doi: 10.1002/lt.25326Hydrogen
2. Funada S, Kita Y,Yoshiyuki Okada, Takashi Kobayashi, Yuki Teramoto, Shinsuke Shibuya, Ryoichi Saito, Kaoru Murakami, Keiyu Matsumoto, Yang Feng, Dimiter S. Dimitrov, Takahiro Inoue, Osamu Ogawa
   Bladder urothelial carcinoma producing insulin‐like growth factor II: A case report
   IJU Case reports 2018 Sep; 1(1): 9-12
   doi: 10.1002/iju5.12018
3. Kaoru Abiko, Tsukasa Baba, Junzo Hamanishi, Ken Yamaguchi, Ryusuke Murakami, Koji Yamanoi, Naoki Horikawa, Yuko Hosoe, Eijiro Nakamura, Aiko Sugiyama, Masaki Mandai, Ikuo Konishi, Noriomi Matsumura
   Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation
   Nat Commun 2018 Apr 27;9(1):1685
   doi: 10.1038/s41467-018-03966-7
4. Shuang Wei, Elaine M Hurt, Michael D Green, Lili Zhao, Linda Vatan, Wojciech Szeliga, Ronald Herbst, Paul W Harms, Leslie A Fecher, Pankaj Vats, Arul M Chinnaiyan, Christopher D Lao, Theodore S Lawrence, Max Wicha, Junzo Hamanishi, Masaki Mandai, Ilona Kryczek, Weiping Zou
   Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression
   J Clin Invest 2018 Apr 2;128(4):1708
   doi: 10.1172/JCI120803
5. Sengiku A,Ueda M, Kono J, Sano T, Nishikawa N, Kunisue S, Tsujihana K, Liou LS, Kanematsu A, Shimba S, Doi M, Okamura H, Ogawa O, Negoro H.
   Circadian coordination of ATP release in the urothelium via connexin43 hemichannels.
   Sci Rep 2018 Jan 31;8(1):1996
   doi: 10.1038/s41598-018-20379-0
6. Jungmi Choi , Hatasu Kobayashi , Hiroko Okuda , Kouji H Harada , Midori Takeda , Hiroyuki Fujimoto , Shunsuke Yamane , Daisuke Tanaka , Shohab Youssefian , Nobuya Inagaki , Akio Koizumi
   β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice
   PLoS One 2018 Jan 5;13(1):e0190863 
   doi: 10.1371/journal.pone.0190863

2017

1. Tomohiro Aoki , Hirokazu Koseki , Miyuki Fukuda , Jun Hirose , Keiichi Tsuji , Katsumi Takizawa , Shinichiro Nakamura , Haruka Miyata , Nozomu Hamakawa , Hidetoshi Kasuya , Kazuhiko Nozaki , Yoshitaka Hirayama, Ichiro Aramori , Shuh Narumiya 
   A sphingosine-1-phosphate receptor type 1 agonist, ASP 4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration
   Br J Pharmacol 2017 Jul;174(13):2085-2101
   doi:10.1111/bph.13820
2. Kaoru Abiko, Noriomi Matsumura, Junzo Hamanishi, Tsukasa Baba, Ken Yamaguchi, Yumiko Yoshioka, Masafumi Koshiyama, Ikuo Konishi
   CCR-16-0387Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells
   Clin Cancer Res 2017 Jan 15;23(2):587-599
   doi: 10.1158/1078-0432